| Product name: |
N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds] |
| CAS RN: |
10416-59-8 |
| SAFETY DATA SHEET: |
| 1、HAZARDS IDENTIFICATION |
| Classification of the substance or mixture |
PHYSICAL HAZARDS |
Flammable liquids Category 2
|
| HEALTH HAZARDS |
Acute toxicity (Oral) Category 4
Acute toxicity (Dermal) Category 3
Skin corrosion/irritation Category 2
Serious eye damage/eye irritation Category 2A
Germ cell mutagenicity Category 2
Specific target organ toxicity
- Single exposure [Category 1]
Respiratory system Central nervous system
Specific target organ toxicity
- Repeated exposure [Category 2]
Liver Blood system Respiratory system Kidney Central
nervous system
|
| ENVIRONMENTAL HAZARDS |
Not classified
|
| Label elements |
Pictograms or hazard symbols |
   |
| Signal word |
Danger |
| Hazard statements |
Highly flammable liquid and vapour
Harmful if swallowed
Toxic in contact with skin
Causes skin irritation
Causes serious eye irritation
Suspected of causing genetic defects
Causes damage to organs : Respiratory system Central
nervous system
May cause damage to organs through prolonged or
repeated exposure : Liver Blood system Respiratory
system Kidney Central nervous system
|
Precautionary statements
[Prevention] |
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Keep away from heat, sparks, open flames and hot surfaces. -No smoking.
Keep container tightly closed
Ground and bond container and receiving equipment.
Use explosion-proof electrical, ventilating and lighting equipment. Use only
non-sparking tools. Take precautionary measures against static discharge.
Do not breathe mist, vapors or spray.
Do not eat, drink or smoke when using this product.
Wash hands and face thoroughly after handling.
Wear protective gloves, protective clothing, face protection
|
| [Response] |
IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse
mouth.
IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or
doctor if you feel unwell. Take off immediately all contaminated clothing and wash
it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get
medical advice or attention.
If exposed or concerned: Call a POISON CENTER or doctor
|
| [Storage] |
Store in a well-ventilated place. Keep cool.
Store locked up |
| [Disposal] |
Dispose of contents and container in accordance with local, regional, national
regulations. |
| 2、COMPOSITION/INFORMATION ON INGREDIENTS |
Substance/mixture: Mixture
Components: N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent,
for NH2 compounds]
Percent: ....
CAS RN: 10416-59-8
Synonyms: BSA (25% in Acetonitrile) , TMS-BA (25% in Acetonitrile)
Chemical Formula: ---
|
| 3、 PHYSICAL AND CHEMICAL PROPERTIES |
Physical state (20°C): Liquid
Form: Clear
Colour: Colorless - Almost colorless
Odour: No data available
pH: No data available
Melting point/freezing point: No data available
(Acetonitrile) -46°C
Boiling point/range: No data available
(Acetonitrile) 82°C
Flash point: No data available (Acetonitrile) 10°C
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: No data available
Solubility(ies):
[Water] No data available
[Other solvents] No data available
Log Pow: (Acetonitrile) -0.3
|
| 4、STABILITY AND REACTIVITY |
Chemical stability: Stable under proper conditions.
Possibility of hazardous reactions: No special reactivity has been reported.
Conditions to avoid: Spark, Open flame, Static discharge
Incompatible materials: Oxidizing agents, Acids, Bases, Reducing agents, Alkali metals
Hazardous decomposition products:Carbon monoxide, carbon dioxide etc
|
The company mainly produces silane-based pharmaceutical raw materials and pharmaceutical intermediates 